ブログ読者の皆さん、ありがとうございます。

おかげさまで、
Ketone body elevation in placenta, umbilical cord,
newborn and mother in normal delivery

と、論文のタイトルを入力して、グーグルで検索するとPDFファイルがトップにでてくるようになりました。

２０１６年１０月１日。午後３：４５。
江部康二


おはようございます。

宗田哲男先生の、胎盤・臍帯・新生児のケトン体値の英文論文が、２０１６年９月３０日（金）いよいよ、インターネットにアップされました。

以下の如く、世界初の革命的な内容の論文です。ヽ(*｀▽´)ノ

【１）胎盤　組織内のケトン体値（βヒドロキシ酪酸）は平均 2235.0 μmol/L、臍帯ケトン体値は、平均779.2μmol/Lであり、胎盤内は有意に高かった(p<0.001)。新生児(4日、30日)のケトン体濃度も標準値よりも高値だった。さらに、臍帯血と胎盤内の血糖値は同様であった（表１）。
２）胎盤組織内のケトン体値は、臍帯血よりも有意に高かった(p<0.001)（図１）。前者は後者の約３倍高く、通常の血液中濃度の標準値(85μmol/L以下)より20-30倍の高値を示した。
３）胎盤組織内の血糖値は75-80 mg/dLであり、すべての妊婦で臍帯血の血糖値と比べて有意差は見られなかった（図２）。】


この論文が世界に広がるために、ブログ読者の皆さんのご協力を是非お願い申し上げます。m(_ _)m

胎盤のケトン体値は、標準値の20～30倍、
臍帯血のケトン体値は、標準値の10倍、
新生児（4日、30日）のケトン体値は標準値の3～4倍、
が、それぞれ普通です。

この論文により、ケトン体の安全性が確立されたと言えます。

英語が苦手な人も得意な人も、兎に角、下記アドレスをクリックして頂けば幸いです。
http://www.toukastress.jp/webj/article/2016/GS16-10.pdf

クリックしたらそのまま論文が出てきます。

論文へのアクセスが増えると、インターネット上で広がる速度が早まります。

ブログ読者の皆さん、クリック、よろしくお願い申し上げます。　m(_ _)mＶＶ


江部康二


☆☆☆
http://www.toukastress.jp/webj/article/2016/GS16-10.pdf

Glycative Stress Research 2016; 3 (3): 133-140
Ketone body elevation in placenta, umbilical cord,
newborn and mother in normal delivery
Tetsuo Muneta 1), Eri Kawaguchi 1), Yasushi Nagai 2), Momoyo Matsumoto 2), Koji Ebe 3),
Hiroko Watanabe 4), Hiroshi Bando 5)

Abstract
Background: Low carbohydrate diets (LCD) have been recently prevalent in the medical and health field, especially in　diabetes mellitus. We have applied LCD on thousands of patients with metabolic diseases and reported the clinical effect of　LCD so far. Through our experience and research concerning LCD, the physiological role of glucose and ketone bodies during　the pre- and post-partum period was investigated in this study.

Subjects and methods: Subjects were 60 normal pregnant woman who had a normal delivery in full-term, without an
abnormal glucose intolerance. Methods included the measurement of the value of ketone bodies in the umbilical cord
blood, placental tissue fluid and maternal blood, associated with the value of blood glucose. As ketone bodies, the value of
3-hydroxybutyric acid (3-OHBA, beta-hydroxybutyric acid) was measured. 3-OHBA and glucose values were measured by
the electrode method using Precision Exceed Kit (Abbott) and the conventional enzymatic cycling method, with comparison
investigation of the data from two kits.

Results: The average 3-OHBA levels were as follows: 2,235.0 μmol/L in the placenta, 779.2 μmol/L in the umbilical cord
blood, in which the former is significantly higher than the latter (p < 0.001), 240.4μmol/L in the newborn after four days,
and 366.7μmol/L after 30 days. The standard 3-OHBA level in a healthy man is less than 85 μmol/L. Glucose levels in the
umbilical cord and placenta were 78.6 mg/dL vs 74.9 mg/dL, with no significant difference, and was the same as that of the
pregnant woman. Accuracy management of the two kits revealed a significant correlation (r = 0.94, p < 0.001). 3-OHBA
values of the maternal blood and umbilical cord blood were extremely elevated from the standard level, with a mutual
significant correlation (r = 0.724, p < 0.001, n = 416).

Conclusion: This clinical study concerning ketone bodies during pre- and post-partum period was investigated, and
revealed that 1) a clinically rapid useful kit for ketone bodies had high reliability and validity compared with conventional
kit, 2) elevated values of 3-OHBA were shown in the placental tissue fluid, umbilical cord, newborn and maternal blood, 3)
3-OHBA would be a physiologically indispensable element in nutrition metabolism for fetus and newborn at least until 30
days, with further development of investigation for ketone bodies.